Tos-PEG4-t-butyl ester [217817-01-1]

MedChem Express

Tos-PEG4-t-butyl ester [217817-01-1]

10

217817-01-1

Research Use Only

99.46

C20H32O8S

432.53

Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].

O=C(OC(C)(C)C)CCOCCOCCOCCOS(=O)(C1=CC=C(C)C=C1)=O

-20°C,2°C to 8°C

41115800