Toyocamycin

MedChem Express

Toyocamycin [606-58-6]

10

606-58-6

99.78

C12H13N5O4

291.26

Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes , acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis . Toyocamycin affects IRE1alpha-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC 50 value of 80 nM with affecting IRE1alpha auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC 50 value of 79 nM [1] [2] [3] .

O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=C(C(N)=NC=N3)C(C#N)=C2

-20°C

12352200