Tozasertib (VX-680)
S1048
CAS Number639089-54-6
Product group Chemicals
Estimated Purity...
Overview
- SupplierSelleck Chemicals
- Product NameTozasertib (VX-680)
- Delivery Days Customer9
- CAS Number639089-54-6
- CertificationResearch Use Only
- Estimated Purity...
- Scientific DescriptionTozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.
- Storage Instruction-80°C
- UNSPSC51202000
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