Trametinib-d4

MedChem Express

Trametinib-d4

10

Research Use Only

C26H19D4FIN5O4

619.42

Trametinib-d4 is the deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

CC(NC1=C(C([2H])=C(C(N(C(C(C(N2C3CC3)=O)=C(NC4=CC=C(I)C=C4F)N5C)=C(C)C5=O)C2=O)=C1[2H])[2H])[2H])=O

12352200