(+/-)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane [257641-01-3]

MedChem Express

(+/-)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane [257641-01-3]

5

257641-01-3

Research Use Only

C10H18N2O2S2

262.39

(+/-)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane is a small-molecule dithiol catalyst with a low thiol pKa value (8.3) and high reduction potential (-0.24 V), capable of mimicking PDI activity. It catalyzes the activation of scrambled ribonuclease A (scrambled ribonuclease A) and promotes the formation of native disulfide bonds, thereby significantly enhancing protein folding efficiency. Adding (+/-)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane to the culture medium of Saccharomyces cerevisiae can increase the secretion of exogenously expressed Schizosaccharomyces pombe acid phosphatase by more than threefold. (+/-)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane holds great potential for applications in protein production and secretion research[1].

SCC(N[C@H]1[C@@H](CCCC1)NC(CS)=O)=O

12352200