TRC210258 [1431553-15-9]
HY-117912
CAS Number1431553-15-9
Product group Chemicals
Molecular Weight396.80
Overview
- SupplierMedChem Express
- Product NameTRC210258 [1431553-15-9]
- Delivery Days Customer9
- CAS Number1431553-15-9
- CertificationResearch Use Only
- Molecular FormulaC20H14ClFN4O2
- Molecular Weight396.80
- Scientific DescriptionTRC210258 is a TGR5 agonist with activity to improve diabetes-associated hyperglycemia and dyslipidemia. TRC210258 promotes energy expenditure by enhancing the release of glucagon-like peptide-1. TRC210258 is able to improve glucose metabolic control in high-fat diet-induced obese mice. TRC210258 also showed improvement in lipid parameters in high-fat-fed hamsters, including reductions in plasma triglyceride and low-density lipoprotein cholesterol levels. TRC210258 improved emerging lipid-related cardiovascular risk parameters including remnant cholesterol and triglyceride clearance[1].
- SMILESO=C(N(C)C1=CC=C(C=C1)Cl)C2=C(N=C3N=CC=CN32)OC4=CC=C(C=C4)F
- UNSPSC12352200