Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA024450ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA024450ESR1HU at dilution of 1:100
TRIM13 Antibody
CSB-PA024450ESR1HU
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetTRIM13
Overview
- SupplierCusabio
- Product NameTRIM13 Antibody
- Delivery Days Customer20
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID10206
- Target nameTRIM13
- Target descriptiontripartite motif containing 13
- Target synonymsB-cell chronic lymphocytic leukemia tumor suppressor Leu5; CAR; CLL-associated RING finger; DLEU5; E3 ubiquitin-protein ligase TRIM13; LEU5; leukemia-associated protein 5; putative tumor suppressor RFP2; ret finger protein 2; RFP2; RING finger protein 77; RING-type E3 ubiquitin transferase TRIM13; RNF77; tripartite motif protein 13; tripartite motif-containing protein 13
- HostRabbit
- IsotypeIgG
- Protein IDO60858
- Protein NameE3 ubiquitin-protein ligase TRIM13
- Scientific DescriptionE3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203