TRIM27 Antibody

Cusabio

TRIM27 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

TRIM27

tripartite motif containing 27

RFP, RNF76, zinc finger protein RFP, RFP transforming protein, RING finger protein 76, RING-type E3 ubiquitin transferase TRIM27, ret finger protein, tripartite motif protein TRIM27, tripartite motif-containing protein 27

Rabbit

IgG

Zinc finger protein RFP

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of Lys-48-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of Lys-63-linked polyubiquitin chains at Lys-220 of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Human

-20°C or -80°C

41116161