Trimetrexate (trihydrochloride) [1658520-97-8]
HY-10373A
CAS Number1658520-97-8
Product group Chemicals
Molecular Weight478.80
Overview
- SupplierMedChem Express
- Product NameTrimetrexate (trihydrochloride) [1658520-97-8]
- Delivery Days Customer10
- CAS Number1658520-97-8
- CertificationResearch Use Only
- Molecular FormulaC19H26Cl3N5O3
- Molecular Weight478.80
- Scientific DescriptionTrimetrexate (CI-898) trihydrochloride is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate trihydrochloride can also inhibit the growth of various cancer cells. Trimetrexate trihydrochloride can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer[1][2][3][4][5].
- SMILESNC1=C(C(C)=C2CNC3=CC(OC)=C(OC)C(OC)=C3)C(C=C2)=NC(N)=N1.[H]Cl.[H]Cl.[H]Cl
- UNSPSC12352200