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Tropomyosin 3 antibody

Research Use Only
GTX109592
GeneTex
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetTPM3
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Overview

  • Supplier
    GeneTex
  • Product Name
    Tropomyosin 3 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.35 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID7170
  • Target name
    TPM3
  • Target description
    tropomyosin 3
  • Target synonyms
    alpha-tropomyosin, slow skeletal; CAPM1; CFTD; cytoskeletal tropomyosin TM30; epididymis luminal protein 189; epididymis secretory sperm binding protein Li 82p; heat-stable cytoskeletal protein 30 kDa; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5; TM3; TM30; TM30nm; TM5; TM-5; TPM3nu; TPMsk3; TRK; tropomyosin 3 nu; tropomyosin alpha-3 chain; tropomyosin gamma; tropomyosin-5
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP06753
  • Protein Name
    Tropomyosin alpha-3 chain
  • Scientific Description
    This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Attenuation of LDHA expression in cancer cells leads to redox-dependent alterations in cytoskeletal structure and cell migration. Arseneault R et al., 2013 Sep 28, Cancer Lett
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