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ProductsBack/TrxR-IN-3 [2445565-58-0]

TrxR-IN-3 [2445565-58-0]

HY-146307
MedChem Express
CAS Number2445565-58-0
DownloadMSDS
Product group Chemicals
Molecular Weight268.23
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Overview

  • Supplier
    MedChem Express
  • Product Name
    TrxR-IN-3 [2445565-58-0]
  • Delivery Days Customer
    10
  • CAS Number
    2445565-58-0
  • Certification
    Research Use Only
  • Molecular Formula
    C14H11F3O2
  • Molecular Weight
    268.23
  • Scientific Description
    TrxR-IN-3 (Compound 2c) is a potent inhibitor of TrxR. TrxR-IN-3 exhibits potent antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and resulted in marked apoptosis by regulating apoptosis-related proteins expressed in the breast cancer cells. TrxR-IN-3 also triggers the formation of autophagosomes and autolysosomes by promoting the expression of LC3-II and Beclin-1 and diminishing the expression of LC3-I and p62 proteins[1].
  • SMILES
    O=C1C=CCC/C1=C\C2=CC=C(OC(F)(F)F)C=C2
  • UNSPSC
    12131703