ts-SA [100715-13-7]

MedChem Express

ts-SA [100715-13-7]

9

100715-13-7

Research Use Only

C14H15N3O5S2

369.42

ts-SA is a carbonic anhydrase (CA) inhibitor with activity against seven human CA homologues. ts-SA can bind to the Zn(II) ion in the enzyme active site in a deprotonated form. The organic skeleton of ts-SA extends in the enzyme cavity and participates in multiple interactions with amino acid residues and water molecules. Due to its structural differences, the inhibitory performance of ts-SA is significantly better than that of another pyridine derivative. ts-SA exhibits low nanomolar inhibitory activity and is a multi-target CA inhibitor[1].

O=S(NC(NC1=CC=C(C=C1)S(=O)(N)=O)=O)(C2=CC=C(C=C2)C)=O

12352200