TSI-01

MedChem Express

TSI-01 [704878-75-1]

5

704878-75-1

Research Use Only

98.31

C14H11Cl2NO4

328.15

TSI-01 is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 ( IC 50 s=0.47 versus 3.02 microM for human LPCAT2 and LPCAT1, respectively). 60 microM it is shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.

O=C(C1=CC=C(N2C(C(Cl)=C(C2=O)Cl)=O)C=C1)OC(C)C

-20°C,2°C to 8°C

12352200