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Tubastatin A hydrochloride [1310693-92-5]

27108

CAS Number1310693-92-5
Product group Chemicals
Estimated Purity≥98%
Molecular Weight371.9 Da
Overview
- SupplierBPS Bioscience
- Product NameTubastatin A hydrochloride
- Delivery Days Customer7
- CAS Number1310693-92-5
- CertificationResearch Use Only
- Estimated Purity≥98%
- Molecular FormulaC20H21N3O2 HCl
- Molecular Weight371.9 Da
- Scientific DescriptionTubastatin A is a potent HDAC6 inhibitor. It demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 microM), excluding HDAC8 (IC50 = 0.9 microM). Tubastatin A induces a-tubulin hyperacetylation at 2.5 microM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, it displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 microM.
- Storage Instruction-20°C
- UNSPSC51202000