Tubastatin A (TFA)

MedChem Express

Tubastatin A (TFA) [1239262-52-2]

14

1239262-52-2

Research Use Only

C22H22F3N3O4

449.42

Tubastatin A (TSA) TFA is a potent and selective HDAC6 inhibitor with IC 50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A TFA also inhibits HDAC10 and metallo-beta-lactamase domain-containing protein 2 (MBLAC2) .

O=C(NO)C1=CC=C(CN2C3=C(CN(C)CC3)C4=C2C=CC=C4)C=C1.O=C(O)C(F)(F)F

12352200