Tubulin polymerization-IN-11

MedChem Express

Tubulin polymerization-IN-11 [2470063-59-1]

10

Research Use Only

C22H22N4O4

406.43

Tubulin polymerization-IN-11 is a potent tubulin polymerization inhibitor with an IC50 value of 3.4 microM. Tubulin polymerization-IN-11 shows antiproliferative activity. Tubulin polymerization-IN-11 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-11 decreases the expression of cyclin B1, p-cdc2, and Bcl-2 protein levels and increases the expression of cleaved PARP[1].

COC1=CC=C(C=C1N)C2=CN3C(C=C2)=NN=C3C4=CC(OC)=C(C(OC)=C4)OC

12131703