Tunlametinib [1801756-06-8]
HY-132844
CAS Number1801756-06-8
Product group Chemicals
Estimated Purity99.53
Molecular Weight491.25
Overview
- SupplierMedChem Express
- Product NameTunlametinib [1801756-06-8]
- Delivery Days Customer10
- CAS Number1801756-06-8
- CertificationResearch Use Only
- Estimated Purity99.53
- Molecular FormulaC16H12F2IN3O3S
- Molecular Weight491.25
- Scientific DescriptionTunlametinib is a highly selective, orally active MEK1/2 inhibitor (IC50=1.9 nM, MEK1). Tunlametinib blocks the RAS-RAF-MEK-ERK signaling pathway, arrests tumor cell cycle and promotes apoptosis. Tunlametinib potently inhibits the proliferation of RAS/RAF mutant cancer cells (such as BRAF V600E, KRAS G12C mutant cells). Tunlametinib shows synergistic anti-tumor effects with BRAF/KRASG12C/SHP2 inhibitors, Docetaxel (HY-B0011). Tunlametinib can be used to study targeted therapy for RAS/RAF mutation-driven malignancies (such as melanoma, colorectal cancer, and non-small cell lung cancer)[1][2].
- SMILESO=C(C1=CC2=C(C(F)=C1NC3=CC=C(C=C3F)I)N=CS2)NOCCO
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200