TWEAK/TNFSF12, Mouse (204a.a, HEK293, rFc)

MedChem Express

TWEAK/TNFSF12, Mouse (204a.a, HEK293, rFc)

14

Research Use Only

95.00

Tnfsf12

tumor necrosis factor (ligand) superfamily, member 12

Apo3l, Dr3l, Dr3lg, Tweak, tumor necrosis factor ligand superfamily member 12, TNF-related weak inducer of apoptosis

Tumor necrosis factor ligand superfamily member 12

TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis[1]. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs)[2]. TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1[3]. Mouse TWEAK protein is a type II transmembrane protein with a transmembrane domain. TWEAK/TNFSF12 Protein, Mouse (HEK293, rFc) is the extracellular part of TWEAK protein, produced by HEK293 cells with N-terminal rFc-tag.

-20°C

41116100

Mouse