TWEAK/TNFSF12, Rat (HEK293, Fc)

MedChem Express

TWEAK/TNFSF12, Rat (HEK293, Fc)

10

Research Use Only

96.20

Tnfsf12

TNF superfamily member 12

TWEAK, Tnlg4a, tumor necrosis factor ligand superfamily member 12, TNF-related weak inducer of apoptosis, tumor necrosis factor ligand 4a, tumor necrosis factor superfamily member 12

Tumor necrosis factor ligand superfamily member 12

TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis[1]. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs)[2]. TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1[3]. TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain. TWEAK/TNFSF12 Protein, Rat (HEK293, Fc) is produced by HEK293 cells (R105-H249) with N-terminal rFc-tag.

-20°C

41116100

Rat