TWIK-1/TREK-1-IN-3 [1440532-33-1]

MedChem Express

TWIK-1/TREK-1-IN-3 [1440532-33-1]

5

1440532-33-1

Research Use Only

99.61

C19H27F3N2O2

372.43

TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 microM and 16.5 microM, respectively, and has antidepressant-like effects[1].

O[C@H](COC1=CC=C(C(F)(F)F)C=C1)CN2CCC(N3CCCC3)CC2

-20°C,2°C to 8°C

12131703