TYK2-IN-12 [2244061-66-1]

MedChem Express

TYK2-IN-12 [2244061-66-1]

10

2244061-66-1

Research Use Only

98.81

C24H20F2N4O2

434.44

TYK2-IN-12 (compound 30) is an orally active, potent and selective TYK2 (tyrosine kinase 2) inhibitor, with a Ki of 0.51 nM. TYK2-IN-12 inhibits IL-12 induced IFNgamma, with IC50 values of 2.7 and 7.0 microM in human and mouse whole blood, respectively. TYK2-IN-12 can be used for psoriasis research[1].

FC1=CC=CC(F)=C1C2=NC(CN3)=C(C(NC4=CC=C(C(N5CCCC5)=O)C=C4)=C2)C3=O

-20°C

12131703