Tyk2-IN-5 [1797432-62-2]

MedChem Express

Tyk2-IN-5 [1797432-62-2]

10

1797432-62-2

Research Use Only

99.35

C21H19FN8O2

434.43

Tyk2-IN-5 (compound 6) is a potent, selective and orally active tyrosine kinase 2 (Tyk2) inhibitor that acts on the JH2 structural domain. Tyk2-IN-5 shows a Ki value of 0.086 nM for Tyk2 JH2 and an IC50 value of 25 nM for IFNalpha. Tyk2-IN-5 efficiently inhibits the production of IFNgamma in a pharmacodynamic rat model and is fully efficacious in a rat model of arthritis[1].

O=C1C(NC2=NN3C(C(NC)=C2)=NC=C3C(N[C@H]4[C@@H](F)C4)=O)=CC=CN1C5=CC=CC=N5

-20°C,2°C to 8°C

12352200