Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker)(TYRP1/3280), 0.2mg/mL [26628-22-8]

Biotium

Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker)(TYRP1/3280), 0.2mg/mL [26628-22-8]

9

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

26628-22-8

Research Use Only

Monoclonal

TYRP1/3280

0.2 mg/ml

TYRP1

tyrosinase related protein 1

CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN, 5,6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, catalase B, glycoprotein 75, melanoma antigen gp75

Mouse

IgG2b

5,6-dihydroxyindole-2-carboxylic acid oxidase

Reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Human

2°C to 8°C,RT

41116161