TZ9, Rad6 Ubiquitin Inhibitor

Bioss

TZ9, Rad6 Ubiquitin Inhibitor

16

Research Use Only

98.0

TZ9 is a selective and cell permeable inhibitor of human E2 ubiquitin-conjugating enzyme Rad6B. It binds to the Rad6B catalytic site, inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular beta-catenin. It can induce G2/M arrest and apoptosis, and inhibit proliferation and migration of metastatic human breast cancer cells (IC50 ~6 microM).

-20°C

51202000