UACA antibody

GeneTex

UACA antibody

9

WB: 1:500 - 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

Unconjugated

UACA

uveal autoantigen with coiled-coil domains and ankyrin repeats

nuclear membrane binding protein; NUCLING; uveal autoantigen with coiled-coil domains and ankyrin repeats

Rabbit

IgG

Uveal autoantigen with coiled-coil domains and ankyrin repeats

This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to negatively regulate apoptosis based on experiments in human cell lines in which the protein was shown to interact with PRKC apoptosis WT1 regulator protein, also known as PAR-4, and inhibit translocation of the PAR-4 receptor. Autoantibodies to this protein have been identified in human patients with panuveitis and Graves disease. Differential expression of this gene has been observed in various human cancers. [provided by RefSeq, May 2017]

Human

-20°C or -80°C,2°C to 8°C

12352203