UACA / Nucling(UACA/1222), CF740 conjugate, 0.1mg/mL

Biotium

UACA / Nucling(UACA/1222), CF740 conjugate, 0.1mg/mL

16

Western Blot

Research Use Only

Monoclonal

UACA/1222

0.1 mg/ml

Other Conjugate

UACA

uveal autoantigen with coiled-coil domains and ankyrin repeats

NUCLING, uveal autoantigen with coiled-coil domains and ankyrin repeats, nuclear membrane binding protein

IgG1

Uveal autoantigen with coiled-coil domains and ankyrin repeats

UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

2°C to 8°C,RT

41116100