UBE2L3 Antibody

Cusabio

UBE2L3 Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

UBE2L3

ubiquitin conjugating enzyme E2 L3

E2-F1, L-UBC, UBCH7, UbcM4, ubiquitin-conjugating enzyme E2 L3, E2 ubiquitin-conjugating enzyme L3, ubiquitin carrier protein L3, ubiquitin conjugating enzyme E2L 3, ubiquitin-conjugating enzyme E2-F1, ubiquitin-conjugating enzyme UBCH7, ubiquitin-protein ligase L3

Rabbit

IgG

Ubiquitin-conjugating enzyme E2 L3

Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.

Human, Mouse

-20°C or -80°C

41116161