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UBE3C antibody [N1N3]

GTX119102
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
TargetUBE3C
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Overview

  • Supplier
    GeneTex
  • Product Name
    UBE3C antibody [N1N3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID9690
  • Target name
    UBE3C
  • Target description
    ubiquitin protein ligase E3C
  • Target synonyms
    HECTH2, NDSMBA, NEDSMBA, RAUL, ubiquitin-protein ligase E3C, HECT-type ubiquitin transferase E3C, RTA-associated ubiquitin ligase, homologous to E6AP carboxyl terminus homologous protein 2, ubiquitin-protein isopeptide ligase (E3)
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ15386
  • Protein Name
    Ubiquitin-protein ligase E3C
  • Scientific Description
    E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either Lys-29- or Lys-48-linked polyubiquitin chains. Has preference for Lys-48 linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Besche HC, Sha Z, Kukushkin NV, et al. Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. EMBO J. 2014,33(10):1159-76. doi: 10.1002/embj.201386906
    Read this paper
  • Chu BW, Kovary KM, Guillaume J, et al. The E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates. J Biol Chem. 2013,288(48):34575-87. doi: 10.1074/jbc.M113.499350
    Read this paper
  • Martínez-Noël G, Galligan JT, Sowa ME, et al. Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. Mol Cell Biol. 2012,32(15):3095-106. doi: 10.1128/MCB.00201-12
    Read this paper