UBE3C antibody [N1N3]
GTX119102
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetUBE3C
Overview
- SupplierGeneTex
- Product NameUBE3C antibody [N1N3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID9690
- Target nameUBE3C
- Target descriptionubiquitin protein ligase E3C
- Target synonymsHECTH2; HECT-type ubiquitin transferase E3C; ubiquitin-protein isopeptide ligase (E3); ubiquitin-protein ligase E3C
- HostRabbit
- IsotypeIgG
- Protein IDQ15386
- Protein NameUbiquitin-protein ligase E3C
- Scientific DescriptionE3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either Lys-29- or Lys-48-linked polyubiquitin chains. Has preference for Lys-48 linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. Besche HC et al., 2014 May 16, EMBO JRead more
- The E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates. Chu BW et al., 2013 Nov 29, J Biol ChemRead more
- Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. Martinez-Noel G et al., 2012 Aug, Mol Cell BiolRead more