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Ubiquilin 1 antibody [N1C1]

Research Use Only
GTX111485
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetUBQLN1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Ubiquilin 1 antibody [N1C1]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID29979
  • Target name
    UBQLN1
  • Target description
    ubiquilin 1
  • Target synonyms
    DA41; DSK2; hPLIC-1; PLIC-1; protein linking IAP with cytoskeleton 1; testicular tissue protein Li 219; ubiquilin-1; UBQN; XDRP1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9UMX0
  • Protein Name
    Ubiquilin-1
  • Scientific Description
    This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimers and Parkinsons disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Inhibitory effect of chloroquine derivatives on presenilin 1 and ubiquilin 1 expression in Alzheimers disease. Zhang FF et al., 2015, Int J Clin Exp Pathol
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