Ubiquilin 4 antibody

GeneTex

Ubiquilin 4 antibody

9

WB: 1 - 2 microg/mL. IHC-P: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

UBQLN4

ubiquilin 4

A1U, A1Up, C1orf6, CIP75, UBIN, ubiquilin-4, Cx43-interacting protein of 75 kDa, ataxin-1 interacting ubiquitin-like protein, ataxin-1 ubiquitin-like interacting protein, ataxin-1 ubiquitin-like-interacting protein A1U, connexin43-interacting protein of 75 kDa

Rabbit

IgG

Ubiquilin-4

The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.

-20°C or -80°C,2°C to 8°C

12352203