Ubiquitin Antibody

Biorbyt

Ubiquitin Antibody

10

Optimal dilution of the Ubiquitin antibody should be determined by the researcher.

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Flow cytometry: 1-2ug/million cells,Western blot: 1-2ug/ml,Immunofluorescence: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT FACS, IF, IHC-P, WB

Research Use Only

Monoclonal

UBB/1748

Unconjugated

RPS27A

ribosomal protein S27a

CEP80, HEL112, S27A, UBA80, UBC, UBCEP1, UBCEP80, eS31, ubiquitin-ribosomal protein eS31 fusion protein, 40S ribosomal protein S27a, epididymis luminal protein 112, ubiquitin C, ubiquitin and ribosomal protein S27a, ubiquitin carboxyl extension protein 80, ubiquitin-40S ribosomal protein S27a, ubiquitin-CEP80

Mouse

IgG2c

Polyubiquitin-B

Ubiquitin is a highly conserved and plays an essential role in the ubiquitin-proteasome pathway. In ubiquitination process, it is first activated by forming a thiol-ester complex with the activation component E1, which is then transferred to ubiquitin-carrier protein E2, followed by to ubiquitin ligase E3 for final delivery to epsilon-NH2 of the target protein lysine residue. IkB, p53, cdc25A, Bcl-2 etc. are shown as targets of ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis. Moreover, ubiquitin have been reported to bind covalently with pathological inclusions which are resistant to degradation e.g. neurofibrillary tangles/paired helical filaments in Alzheimers disease, Lewy bodies seen in Parkinsons disease, and Pick bodies found in Picks disease etc.

Human

-20°C,2°C to 8°C

12352203