Ubiquitin B antibody [3C12]

GeneTex

Ubiquitin B antibody [3C12]

9

WB: 1/500 - 1/2000. FACS: 1/200 - 1/400. ELISA: 1/10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, Western Blot, ELISA

Research Use Only

Monoclonal

3C12

1 mg/ml

Unconjugated

UBB

ubiquitin B

epididymis secretory protein Li 50; HEL-S-50; polyubiquitin B; polyubiquitin-B

Mouse

IgG1

Polyubiquitin-B

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimers and Down syndrome. [provided by RefSeq, Jul 2008]

-20°C or -80°C,2°C to 8°C

12352203