UC2288
M11331
CAS Number1394011-91-6
Product group Chemicals
Molecular Weight481.82
Overview
- SupplierAbMole BioScience
- Product NameUC2288
- Delivery Days Customer9
- CAS Number1394011-91-6
- Category SupplierChemical
- CertificationResearch Use Only
- Molecular FormulaC20H18ClF6N3O2
- Molecular Weight481.82
- Scientific DescriptionUC2288 is a novel p21 attenuator with cellular permeability and oral activity (relatively selective activity for P21), based on the structural synthesis of sorafenib. UC2288 down-regulated the expression of P21 mRNA and reduced the level of P21 protein independently of p53, and had little effect on the stability of P21 protein. UC2288 did not inhibit VEGFR2 and Raf kinases, even at 10 uM.
- SMILESFC(F)(F)C1=CC=C(OC2CCC(CC2)NC(=O)NC3=CC(=C(Cl)C=C3)C(F)(F)F)N=C1
- UNSPSC12352200