Ucf-101 [313649-08-0]

MedChem Express

Ucf-101 [313649-08-0]

10

313649-08-0

Research Use Only

99.65

C27H17N3O5S

495.51

Ucf-101 is a selective and competitive inhibitor of pro-apoptotic protease Omi/HtrA2, with an IC50 of 9.5 microM for His-Omi. Ucf-101 exhibits very little activity against various other serine proteases (IC50>200 microM). Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant cardioprotective effect against MI/R injury and also has certain neuroprotective effect[1][2][3].

O=C(/C(C(N1C2=CC=CC=C2)=O)=C/C3=CC=C(C4=C([N+]([O-])=O)C=CC=C4)O3)N(C5=CC=CC=C5)C1=S

-20°C,2°C to 8°C

12352200