UCHL3 Recombinant Protein

Aviva Systems Biology

UCHL3 Recombinant Protein

23

Western Blot, Other Application

Research Use Only

200 ug/ml

Unconjugated

>95%

Lyophilized

Uchl3

ubiquitin C-terminal hydrolase L3

RGD1561196, UCH-L3, ubiquitin carboxyl-terminal hydrolase isozyme L3, ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase), ubiquitin thioesterase L3

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3, and exhibits a preference towards Lys-48-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome (By similarity).

E.coli

-80°C,2°C to 8°C

41116100

Rat