UCK2 Inhibitor-3 [2376687-49-7]
HY-148396
CAS Number2376687-49-7
Product group Chemicals
Molecular Weight474.31
Overview
- SupplierMedChem Express
- Product NameUCK2 Inhibitor-3 [2376687-49-7]
- Delivery Days Customer10
- CAS Number2376687-49-7
- CertificationResearch Use Only
- Molecular FormulaC19H13BrFN5O2S
- Molecular Weight474.31
- Scientific DescriptionUCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2, a pyrimidine salvage enzyme) with an IC50 value of 16.6 microM. UCK2 can replace dihydroorotate dehydrogenase (DHODH), in a certain extent, in infected or rapidly dividing cells to continue efficient uridine salvage. UCK2 Inhibitor-3 also inhibits DNA polymerase eta and kappa with IC50s of 56 microM and 16 microM[1].
- SMILESO=C(NC1=CC=C(Br)C=C1)CSC(N=C2C3=CNN2C4=CC=C(F)C=C4)=NC3=O
- UNSPSC12131703