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UCK2 Inhibitor-3 [2376687-49-7]

HY-148396
MedChem Express
CAS Number2376687-49-7
Product group Chemicals
Molecular Weight474.31
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Overview

  • Supplier
    MedChem Express
  • Product Name
    UCK2 Inhibitor-3 [2376687-49-7]
  • Delivery Days Customer
    10
  • CAS Number
    2376687-49-7
  • Certification
    Research Use Only
  • Molecular Formula
    C19H13BrFN5O2S
  • Molecular Weight
    474.31
  • Scientific Description
    UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2, a pyrimidine salvage enzyme) with an IC50 value of 16.6 microM. UCK2 can replace dihydroorotate dehydrogenase (DHODH), in a certain extent, in infected or rapidly dividing cells to continue efficient uridine salvage. UCK2 Inhibitor-3 also inhibits DNA polymerase eta and kappa with IC50s of 56 microM and 16 microM[1].
  • SMILES
    O=C(NC1=CC=C(Br)C=C1)CSC(N=C2C3=CNN2C4=CC=C(F)C=C4)=NC3=O
  • UNSPSC
    12131703