UIMC1 Antibody

Cusabio

UIMC1 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

UIMC1

ubiquitin interaction motif containing 1

RAP80, X2HRIP110, BRCA1-A complex subunit RAP80, receptor-associated protein 80, retinoid X receptor-interacting protein 110

Rabbit

IgG

BRCA1-A complex subunit RAP80

Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds Lys-63-linked ubiquitin (PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than Lys-63-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

Human, Rat

-20°C or -80°C

41116161