Western Blot Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate, Rat kidney tissue All lanes: UIMC1 antibody at 3microg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 80, 62, 71, 39, 18 kDa Observed band size: 80 kDa

UIMC1 Antibody

Name: UIMC1 Antibody
SKU: CSB-PA857019LA01HU_C90
Availability: BackOrder

CSB-PA857019LA01HU

ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry

Product group Antibodies

TargetUIMC1

Overview

Supplier
Cusabio
Product Name
UIMC1 Antibody
Delivery Days Customer
20
Applications
Western Blot, ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID51720
Target name
UIMC1
Target description
ubiquitin interaction motif containing 1
Target synonyms
BRCA1-A complex subunit RAP80; RAP80; receptor-associated protein 80; retinoid X receptor-interacting protein 110; X2HRIP110
Host
Rabbit
Isotype
IgG
Protein IDQ96RL1
Protein Name
BRCA1-A complex subunit RAP80
Scientific Description
Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds Lys-63-linked ubiquitin (PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than Lys-63-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Storage Instruction
-20°C or -80°C
UNSPSC
12352203

UIMC1 Antibody

Large volume orders?

Overview

Related products