UK-101

MedChem Express

UK-101 [1000313-40-5]

10

1000313-40-5

Research Use Only

99.58

C25H48N2O5Si

484.74

UK-101 is a potent and selective immunoproteasome beta1i (LMP2) inhibitor with an IC50 value of 104 nM, displays 144- and 10-fold selectivity over beta1c (IC50=15 microM) and beta5 subunit (IC50=1 microM), respectivey[1]. UK-101 induces cell apoptosis and can be used for the study of prostate cancer[2].

O=C([C@]1(CO1)CO[Si](C)(C)C(C)(C)C)[C@H](CC(C)C)NC([C@H](C)NC(CCCCCC)=O)=O

-20°C,2°C to 8°C

12352200