ULBP2 Antibody

Cusabio

ULBP2 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

ULBP2

UL16 binding protein 2

ALCAN-alpha, N2DL2, NKG2DL2, RAET1H, RAET1L, UL16-binding protein 2, NKG2D ligand 2, retinoic acid early transcript 1H, retinoic acid early transcript 1L

Rabbit

IgG

UL16-binding protein 2

Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Human

-20°C or -80°C

41116161