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ULK2 antibody [C2C3], C-term

Research Use Only
GTX111476
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetULK2
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Overview

  • Supplier
    GeneTex
  • Product Name
    ULK2 antibody [C2C3], C-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.24 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID9706
  • Target name
    ULK2
  • Target description
    unc-51 like autophagy activating kinase 2
  • Target synonyms
    ATG1B; serine/threonine-protein kinase ULK2; Unc51.2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ8IYT8
  • Protein Name
    Serine/threonine-protein kinase ULK2
  • Scientific Description
    This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types. Umar S et al., 2021 Dec, Cell Mol Life Sci
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  • Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes. Mohamud Y et al., 2020 Nov 4, Sci Rep
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  • TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy. Nozawa T et al., 2020 Feb 7, Nat Commun
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  • Overexpression of Ulk2 inhibits proliferation and enhances chemosensitivity to cisplatin in non-small cell lung cancer. Cheng H et al., 2019 Jan, Oncol Lett
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  • RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway. Heo JM et al., 2018 Nov, Sci Adv
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