UMI-77

MedChem Express

UMI-77 [518303-20-3]

10

518303-20-3

Research Use Only

99.66

C18H14BrNO5S2

468.34

UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 microM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

O=C(O)CSC1=CC(NS(=O)(C2=CC=C(Br)C=C2)=O)=C3C=CC=CC3=C1O

-20°C,2°C to 8°C

12352200