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Chemical Structure
Chemical Structure
Chemical Structure

Umifenovir Lipodisq Sterile Solution [131707-23-8]

Research Use Only
IAX-700-106
Innaxon
Product group Molecular Biology
Price on request
Packing Size
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Overview

  • Supplier
    Innaxon
  • Product Name
    Umifenovir Lipodisq Sterile Solution [131707-23-8]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Scientific Description
    Chemical. CAS: 131707-23-8. Formula: C22H25BrN2O3S . HCl. MW: 477.4 . 36.5. Umifenovir Lipodisq Sterile Solution is a ready-to-use nano-formulated aqueous solution. Umifenovir (Arbidol) is known to have broad-spectrum anti-viral activity and has earlier been approved in China and Russia for treating influenza, SARS, and Lassa viruses. It has been tested in multiple clinical studies as a candidate for use as an anti-COVID19 therapeutic and has been suggested to act at the entry stage and at the post-entry stages by preventing viral attachment and inhibiting the release of virus particles from intracellular vesicles, respectively. In a recent phase III, clinical study Umifenovir met the primary and secondary endpoint criteria. It has been shown to efficacious, safe and well-tolerated at the tested dosage. Umifenovir Lipodisq is based on a nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilized by a chaperone molecule annulus. Internal properties of the phospholipid membrane support the disposition and stabilization of drug molecule candidates and preserve the native conformation of membrane molecules. The resulting encapsulated actives are rendered water-soluble and specialized for intra-cellular penetration/delivery via endosomal uptake mechanisms. Lipodisq solutions show a good safety profile and are suitable for in vitro and in vivo investigations. - Umifenovir Lipodisq Sterile Solution is a ready-to-use nano-formulated aqueous solution. Umifenovir (Arbidol) is known to have broad-spectrum anti-viral activity and has earlier been approved in China and Russia for treating influenza, SARS, and Lassa viruses. It has been tested in multiple clinical studies as a candidate for use as an anti-COVID19 therapeutic and has been suggested to act at the entry stage and at the post-entry stages by preventing viral attachment and inhibiting the release of virus particles from intracellular vesicles, respectively. In a recent phase III, clinical study Umifenovir met the primary and secondary endpoint criteria. It has been shown to efficacious, safe and well-tolerated at the tested dosage. Umifenovir Lipodisq is based on a nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilized by a chaperone molecule annulus. Internal properties of the phospholipid membrane support the disposition and stabilization of drug molecule candidates and preserve the native conformation of membrane molecules. The resulting encapsulated actives are rendered water-soluble and specialized for intra-cellular penetration/delivery via endosomal uptake mechanisms. Lipodisq solutions show a good safety profile and are suitable for in vitro and in vivo investigations.
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    41116133