UNC 1025 [1350549-36-8]
T60197
CAS Number1350549-36-8
Product group Chemicals
Estimated Purity99.60%
Molecular Weight514.64
Overview
- SupplierTargetMol Chemicals
- Product NameUNC 1025 [1350549-36-8]
- Delivery Days Customer9
- CAS Number1350549-36-8
- CertificationResearch Use Only
- Chemical NameUNC 1025
- Estimated Purity99.60%
- Molecular FormulaC25H34N6O4S
- Molecular Weight514.64
- Scientific DescriptionUNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. Notably, UNC1062 demonstrates potent inhibition of MERTK kinase activity, with an IC50 of 1.1 nM and a Morrison Ki of 0.33 nM. It also displays specificity within the TAM family, exhibiting IC50 values of 60 nM for TYRO3 and 85 nM for AXL [1].
- Shelf life instruction3 years
- SMILESCCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
- Storage Instruction-20°C
- UNSPSC12352200
References
- Schlegel J, Sambade MJ, Sather S, et al. MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J Clin Invest. 2013,123(5):2257-67. doi: 10.1172/JCI67816Read this paper
MSDS
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