UNC-2170 (maleate) [2173992-60-2]

MedChem Express

UNC-2170 (maleate) [2173992-60-2]

5

2173992-60-2

Research Use Only

C18H25BrN2O5

429.31

UNC-2170 maleate is the maleate salt form of UNC-2170 (HY-115531). UNC-2170 maleate is a selective inhibitor for the methyl-lysine binding protein 53BP1, with IC50 of 29 microM and Kd of 22 microM. UNC-2170 maleate shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB)[1].

O=C(NCCCNC(C)(C)C)C1=CC=CC(Br)=C1.O=C(O)/C=C/C(O)=O

12352200