UNC13B antibody [N2N3]

GeneTex

UNC13B antibody [N2N3]

9

WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

UNC13B

unc-13 homolog B

MUNC13, UNC13, Unc13h2, munc13-2, protein unc-13 homolog B, homolog of rat Munc13 (diacylglycerol-binding), unc-13-like

Rabbit

IgG

Protein unc-13 homolog B

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq]

Human, Rat

-20°C or -80°C,2°C to 8°C

41116161