Unesbulin

MedChem Express

Unesbulin [1610964-64-1]

10

1610964-64-1

Research Use Only

99.45

C19H13F5N6

420.34

Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 ( BMI-1 ) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity [1] [2] .

NC1=C(F)C(NC2=CC=C(C(F)(F)F)C=C2)=NC(N3C4=CC(F)=CC=C4N=C3C)=N1

-20°C,2°C to 8°C

12352200