uPA antibody

GeneTex

uPA antibody

9

10 mg/ml

Liquid

PLAU

plasminogen activator, urokinase

ATF; BDPLT5; plasminogen activator, urinary; QPD; UPA; u-PA; U-plasminogen activator; URK; urokinase-type plasminogen activator

Urokinase-type plasminogen activator

This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimers disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

-20°C or -80°C,2°C to 8°C

12352203