Upadacitinib-15N,d2

MedChem Express

Upadacitinib-15N,d2

14

Research Use Only

99.12

C17H17D2F3N5 15NO

383.37

Upadacitinib-15N,d2 (ABT-494-15N,d2) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib-15N,d2 (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib-15N,d2 (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib-15N,d2 (ABT-494) can be used for several autoimmune disorders research[1][2].

CC[C@H]1[C@H](CN(C1)C([15NH]C([2H])([2H])C(F)(F)F)=O)C2=CN=C3C=NC(NC=C4)=C4N23

-20°C,2°C to 8°C

12352200