URAT1&XO inhibitor 2

Biorbyt

URAT1&XO inhibitor 2

10

Research Use Only

98.00%

C14H12BrNO3

322.15

Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 microM for XO inhibition. It effectively impedes uric acid uptake in HEK293 cells with URAT1 expression, evidenced by a Ki of 0.145 microM. In hyperuricemic mice models, the compound has been shown to reduce serum urate levels and uric acid excretion, indicating potential utility for hyperuricemia research [1].

C(\CC1=CC=C(Br)C=C1)(=N\O)/C2=C(O)C=C(O)C=C2

-20°C

12352200