Chemical Structure
Chemical Structure
URMC-099 [1229582-33-5]
SYN-1211
CAS Number1229582-33-5
Product group Chemicals
Estimated Purity>95%
Molecular Weight421.5
Overview
- SupplierSYNkinase
- Product NameURMC-099 [1229582-33-5]
- Delivery Days Customer10
- CAS Number1229582-33-5
- CertificationResearch Use Only
- Estimated Purity>95%
- Molecular FormulaC27H27N5
- Molecular Weight421.5
- Scientific DescriptionChemical. CAS: 1229582-33-5. Formula: C27H27N5. MW: 421.5. Inhibition of mixed lineage kinase 3 (MLK-3) is a potential strategy for the treatment of Parkinsons disease and HIV-1 associated neuro-cognitive disorders (HAND), requiring an inhibitor that can achieve significant brain concentration levels. URMC-099 is an orally bioavailable MLK-3 inhibitor with excellent brain exposure in mouse PK models and minimal interference with key human CYP450 enzymes or hERG channels. URMC-099 inhibits multiple kinase pathways, including MLK-3 (14nM) and leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (11nM). - Inhibition of mixed lineage kinase 3 (MLK-3) is a potential strategy for the treatment of Parkinsons disease and HIV-1 associated neuro-cognitive disorders (HAND), requiring an inhibitor that can achieve significant brain concentration levels. URMC-099 is an orally bioavailable MLK-3 inhibitor with excellent brain exposure in mouse PK models and minimal interference with key human CYP450 enzymes or hERG channels. URMC-099 inhibits multiple kinase pathways, including MLK-3 (14nM) and leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (11nM).
- Storage Instruction2°C to 8°C
- UNSPSC51202000